A comprehensive tool box for large animal studies of intervertebral disc degeneration
نویسندگان
چکیده
منابع مشابه
Efficacy of Platelet-Rich Plasma in Retarding Intervertebral Disc Degeneration: A Meta-Analysis of Animal Studies
OBJECTIVES Several animal studies have demonstrated the positive effects of platelet-rich plasma (PRP) on disc degeneration retardation. The present meta-analysis was to verify the efficacy of PRP in retarding disc degeneration in animal. METHODS Relevant studies were identified and evaluated according to our inclusion and exclusion criteria. The standardized mean difference (SMD) and related...
متن کاملRecapitulating the Spectrum of Intervertebral Disc Degeneration in a Large Animal Model
Images for quantitative T1δ and T2 mapping were obtained, as well as T2 weighted images for Pfirrmann grading. Correlations between quantitative MRI parameters and Pfirrmann grade were established by linear regression. Individual motion segments were then imaged using high resolution microcomputed tomography (μCT) to visualize and quantify morphologic changes to the vertebral bony endplate. Alc...
متن کاملA large animal model that recapitulates the spectrum of human intervertebral disc degeneration.
OBJECTIVE The objective of this study was to establish a large animal model that recapitulates the spectrum of intervertebral disc degeneration that occurs in humans and which is suitable for pre-clinical evaluation of a wide range of experimental therapeutics. DESIGN Degeneration was induced in the lumbar intervertebral discs of large frame goats by either intradiscal injection of chondroiti...
متن کاملDegeneration of the intervertebral disc
The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry, but morphologically it is clearly different. It shows degenerative and ageing changes earlier than does any other connective tissue in the body. It is believed to be important clinically because there is an association of disc degeneration with back pain. Current treatments are predomina...
متن کاملStudies of Molecular Changes in Intervertebral Disc Degeneration in Animal Model
OBJECTIVE To evaluate the structural and molecular changes in the extracellular matrix (ECM) during the process of intervertebral disc degeneration, using animal model. METHODS Wistar rats underwent intervertebral disc degeneration through 20-gauge needle puncture, and 360° rotation applied for 30 sec, representing the degenerated group, while control group was not submitted to this procedure...
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ژورنال
عنوان ژورنال: JOR SPINE
سال: 2021
ISSN: 2572-1143,2572-1143
DOI: 10.1002/jsp2.1162